S100A4 Knockout Sensitizes Anaplastic Thyroid Carcinoma Cells Harboring BRAFV600E/Mt to Vemurafenib
Background/Aims: Anaplastic thyroid cancer Oversized Blanket Hoodie (ATC), with 25% BRAFV600E mutation, is one of the most lethal human malignancies that currently has no effective therapy.Vemurafenib, a BRAFV600E inhibitor, has shown promise in clinical trials, including ATC patients, but is being hampered by the acquisition of drug resistance.The